Libor Kopkan Selected Research

Malignant Hypertension

1/2019	The exaggerated salt-sensitive response in hypertensive transgenic rats (TGR mRen-2) fostered by a normotensive female.
10/2018	20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats.
12/2016	Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats.
10/2016	Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats.
4/2016	Intrarenal alterations of the angiotensin-converting enzyme type 2/angiotensin 1-7 complex of the renin-angiotensin system do not alter the course of malignant hypertension in Cyp1a1-Ren-2 transgenic rats.
12/2014	Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.
2/2013	Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME.
1/2011	Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension.

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Libor Kopkan Research Topics

Disease

29	Hypertension (High Blood Pressure) 01/2019 - 01/2004
8	Malignant Hypertension 01/2019 - 01/2011
5	Body Weight (Weight, Body) 01/2017 - 03/2006
4	Renovascular Hypertension (Goldblatt Syndrome) 01/2017 - 01/2012
4	Cardiomegaly (Heart Hypertrophy) 01/2017 - 01/2004
4	Proteinuria 02/2010 - 01/2004
3	Chronic Renal Insufficiency 01/2019 - 12/2010
2	Heart Failure 01/2021 - 01/2019
2	Albuminuria 01/2019 - 01/2017
2	Myocardial Infarction 10/2015 - 06/2012
1	Hypoxia (Hypoxemia) 01/2021
1	Fistula 01/2019
1	Ischemia 01/2018
1	Kidney Diseases (Kidney Disease) 01/2016
1	Chronic Kidney Failure (Chronic Renal Failure) 12/2010
1	Hypertrophy 02/2010
1	Sclerosis 02/2010

Drug/Important Bio-Agent (IBA)

14	Angiotensin IIIBA 10/2018 - 08/2005
12	ReninIBA 10/2018 - 01/2004
11	Antihypertensive Agents (Antihypertensives)IBA 01/2018 - 07/2007
8	Epoxide HydrolasesIBA 01/2019 - 01/2011
8	indole-3-carbinolIBA 10/2018 - 01/2011
7	XenobioticsIBA 10/2018 - 08/2011
6	SaltsIBA 01/2019 - 01/2004
6	AcidsIBA 01/2019 - 02/2010
6	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2016 - 10/2005
6	Superoxides (Superoxide)IBA 09/2010 - 10/2005
4	SodiumIBA 01/2019 - 01/2006
4	20-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 10/2018 - 02/2010
4	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 10/2018 - 02/2010
3	CreatinineIBA 01/2019 - 01/2004
3	Mixed Function Oxygenases (Monooxygenases)IBA 10/2018 - 12/2016
3	AngiotensinsIBA 01/2016 - 01/2004
3	tempolIBA 08/2009 - 03/2006
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2021 - 12/2010
2	EnzymesIBA 01/2019 - 01/2017
2	angiotensin I (1-7)IBA 01/2017 - 04/2016
2	Fenofibrate (CiL)FDA LinkGeneric 01/2017 - 12/2016
2	Arachidonic Acid (Vitamin F)IBA 01/2017 - 02/2010
2	Endothelins (Endothelin)IBA 01/2017 - 01/2004
2	Pharmaceutical PreparationsIBA 12/2016 - 01/2007
2	Vasodilator Agents (Vasodilators)IBA 04/2016 - 02/2010
2	14,15-epoxy-5,8,11-eicosatrienoic acidIBA 01/2016 - 10/2015
2	salicylhydroxamic acid (SHAM)IBA 01/2016 - 01/2010
2	Losartan (Cozaar)FDA LinkGeneric 08/2011 - 12/2010
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2021
1	Nifedipine (Adalat)FDA LinkGeneric 01/2019
1	fasudil (AT 877)IBA 01/2019
1	Hydroxyeicosatetraenoic Acids (HETE)IBA 01/2017
1	LipidsIBA 12/2016
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 04/2016
1	KininsIBA 01/2016
1	Bradykinin B2 ReceptorIBA 01/2016
1	Tacrolimus (Prograf)FDA LinkGeneric 08/2014
1	Metoprolol (Toprol-XL)FDA LinkGeneric 08/2014
1	Amlodipine (Norvasc)FDA LinkGeneric 08/2014
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 02/2013
1	Benzoic Acid (Potassium Benzoate)FDA Link 06/2012
1	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 12/2010
1	Furosemide (Lasix)FDA LinkGeneric 12/2010
1	DiureticsIBA 12/2010
1	Labetalol (Normodyne)FDA LinkGeneric 12/2010
1	trandolapril (Mavik)FDA LinkGeneric 12/2010
1	Vasoconstrictor AgentsIBA 02/2010
1	meglumine ioxithalamateIBA 01/2010
1	acetovanillone (apocynin)IBA 08/2009
1	8-epi-prostaglandin F2alphaIBA 08/2009
1	AntioxidantsIBA 08/2009
1	OligodeoxyribonucleotidesIBA 07/2007
1	Antisense OligonucleotidesIBA 07/2007
1	candesartanIBA 01/2007
1	Nitric Oxide Synthase (NO Synthase)IBA 03/2006
1	Drinking WaterIBA 03/2006
1	arginine methyl esterIBA 03/2006
1	Bosentan (Tracleer)FDA Link 01/2004

Therapy/Procedure

3	Therapeutics 01/2018 - 12/2010
3	Surgical Instruments (Clip) 10/2015 - 06/2011
1	Oral Administration 01/2011